SAMe and Depression

The body uses SAMe to make certain chemicals that play a role in depression. People who don’t make enough SAMe naturally may be helped by taking SAMe as a supplement.

Some research suggests that SAMe is more effective than placebo in treating mild-to-moderate depression, is just as effective as antidepressant medications without the side effects, and begins to work more quickly, often within one week.

Higher SAMe levels in the brain are associated with successful drug treatment of depression, and oral SAMe has been demonstrated to be an effective treatment for depression in most but not all clinical trials. Most trials use 800 - 1,600 mg of SAMe per day, in 2 divided doses (morning and afternoon).

http://www.umm.edu/altmed/articles/s-adenosylmethionine-000324.htm