Safety

SAMe has been well tolerated in the majority of clinical trials conducted. The most common adverse effects reported are gastrointestinal in nature, mainly nausea, and skin rashes. Other side effects include headache, gas, vomiting, dry mouth, diarrhea, anxiety, a feeling of elation, restlessness, and insomnia. The use of SAMe has not been adequately studied in the pediatric and elderly population, in pregnancy other than the third trimester, or during breastfeeding. People with bipolar disorder (manic-depression) should not take SAMe since it may worsen manic episodes and SAMe should not be combined with other antidepressants without first consulting your doctor.

SAMe may also lower blood sugar levels. Caution is advised in patients with diabetes or hypoglycemia, and in those taking drugs, herbs, or supplements that affect blood sugar. Serum glucose levels may need to be monitored by a healthcare professional and medication adjustments may be necessary.